Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Transcriptional Activator Rta Is an Oligomeric DNA-Binding Protein That Interacts with Tandem Arrays of Phased A/T-Trinucleotide Motifs.
AuthorsLiao W, Tang Y, Kuo YL, Liu BY, Xu CJ, Giam CZ,
JournalJ Virol
PubMed ID12915555
'Kaposi''s sarcoma associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8) encodes an immediate early transcriptional activator, Rta, which mediates viral reactivation from latency and lytic viral replication. Here we report the purification and characterizations of HHV-8 Rta and its interaction with Rta-responsive DNA elements. The Rta response element (RtaRE) in the promoter ... More
Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.
Authors Miyoshi Keiko; Shillingford Jonathan M; Le Provost Fabienne; Gounari Fotini; Bronson Roderick; von Boehmer Harald; Taketo Makoto M; Cardiff Robert D; Hennighausen Lothar; Khazaie Khashayarsha;
JournalProc Natl Acad Sci U S A
PubMed ID11773619
'Mammary anlagen are formed in the embryo as a derivative of the epidermis, a process that is controlled by Lef-1 and therefore possibly by beta-catenin. To investigate the role of beta-catenin signaling in mammary alveolar epithelium, we have stabilized endogenous beta-catenin in differentiating alveolar epithelium through the deletion of exon ... More
Anti-apoptotic Signaling of Pleiotrophin through Its Receptor, Anaplastic Lymphoma Kinase.
Authors Bowden Emma T; Stoica Gerald E; Wellstein Anton;
JournalJ Biol Chem
PubMed ID12107166
The secreted growth factor pleiotrophin (PTN) can induce mitogenesis in cells that express the receptor for this growth factor, anaplastic lymphoma kinase (ALK). Here we examine the ability of PTN to produce anti-apoptotic signals. We demonstrate that PTN is a survival factor for SW-13 epithelial cells and show that ribozyme-mediated ... More