BACE2 functions as an alternative alpha-secretase in cells.
Authors Yan R; Munzner J B; Shuck M E; Bienkowski M J;
JournalJ Biol Chem
PubMed ID11423558
BACE1 and BACE2 define a new subfamily of membrane-anchored aspartyl proteases. Both endoproteases share similar structural organization including a prodomain, a catalytic domain formed via DTG and DSG active site motifs, a single transmembrane domain, and a short C-terminal tail. BACE1 has been identified as the Alzheimer's beta-secretase, whereas BACE2 ... More