Pretreatment with lornoxicam, a cyclooxygenase inhibitor, relieves postoperative immuno-suppression after total abdominal hysterectomy.
AuthorsJiao H, Ren F
JournalTohoku J Exp Med
PubMed ID19966527
'Total abdominal hysterectomy (TAH) is most commonly performed for benign lesions and malignant diseases of the uterus. Postoperative immuno-suppression caused by TAH has become a serious clinical problem, due to the high incidence of infectious complications after this operation. Lornoxicam (LOR) is a member of non-steroidal anti-inflammatory drugs and a ... More
Monoclonal light chain--mesangial cell interactions: early signaling events and subsequent pathologic effects.
AuthorsRussell WJ, Cardelli J, Harris E, Baier RJ, Herrera GA
JournalLab Invest
PubMed ID11351041
'Glomerulopathic monoclonal light chains (G-LC) interact with mesangial cells (MC), resulting in alterations of mesangial homeostasis. Early signaling events control mitogenic activities and cytokine production, which in turn participate in the subsequent pathologic events. Mesangial homeostasis is affected in two very different ways, depending on whether the G-LC is from ... More
Elevated serum chemokine levels in Behçet's disease with uveitis.
AuthorsBozkurt N, Kazokoglu H, Yavuz S, Bavbek T, Direskeneli H
JournalRheumatol Int
PubMed ID12712257
Inflammation but not oxidative stress is associated with beta-chemokine levels and prevalence of cardiovascular disease in uraemic patients.
AuthorsPawlak K, Pawlak D, Mysliwiec M
JournalCytokine
PubMed ID17070067
'Inflammation and oxidative stress (SOX) have been reported in patients with chronic renal failure (CRF), but their influence on beta-chemokines levels and cardiovascular disease (CVD) prevalence remains unknown. We assessed beta-chemokines, SOX markers and high sensitivity C-reactive protein (hs CRP) as a marker of inflammation in 40 uraemic patients, both ... More
CC-chemokine activation in acute pancreatitis: enhanced release of monocyte chemoattractant protein-1 in patients with local and systemic complications.
AuthorsRau B, Baumgart K, Krüger CM, Schilling M, Beger HG
JournalIntensive Care Med
PubMed ID12589535
'Systemic leukocyte activation is claimed to trigger inflammatory response and remote organ dysfunction in acute pancreatitis. Chemokines are inflammatory mediators with potent leukocyte-activating properties and have been shown to be involved in the pathophysiological process of experimental acute pancreatitis. However, as little is known about their role in human disease ... More
Transcription and translation of the chemokines RANTES and MCP-1 in nasal polyps and mucosa in allergic and non-allergic rhinopathies.
AuthorsMarcella R, Croce A, Moretti A, Barbacane RC, Di Giocchino M, Conti P
JournalImmunol Lett
PubMed ID14687706
'The pathogenetic findings of rhinopathies show an increase in infiltrating cells including eosinophils. RANTES is a beta chemokine in which the cysteines are adjacent (C-C), and it attracts and activates eosinophil. We hypothesize that RANTES is locally produced within the nasal polyp microenvironment and is responsible for the inflammatory cell ... More
Oxidative stress influences CC-chemokine levels in hemodialyzed patients.
AuthorsPawlak K, Pawlak D, Mysliwiec M
JournalNephron Physiol
PubMed ID15122056
Increased oxidative stress (SOX) has been reported in hemodialyzed (HD) patients, but its influence on CC-chemokine levels remains unknown.
Three-dimensional culture and multidrug resistance: effects on immune reactivity of MCF-7 cells by monocytes.
AuthorsMougel L, Tarpin M, Albert P, Le Naour R, Devy J, Kaplan H, Ventéo L, Carlier A, Madoulet C
JournalAnticancer Res
PubMed ID15161047
Multicellular spheroids are known to be the most adapted model to keep the in vitro resistance properties of cells. This in vivo-like tissue-culture representation was applied to investigate the immune reactivity of MCF-7 cells by monocytes. ... More
Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus.
The hypothesis was tested in an exploratory study that individuals at high risk of developing Type 1 diabetes mellitus have altered systemic levels of cytokines and chemokines. ... More
MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes.
AuthorsYuasa S, Maruyama T, Yamamoto Y, Hirose H, Kawai T, Matsunaga-Irie S, Itoh H
JournalDiabetes Res Clin Pract
PubMed ID19781803
Cardiovascular diseases are the major cause of mortality in patients with diabetes mellitus. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine and plays an important role in cardiovascular diseases. The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development ... More
Differential chemokine response of fibroblast subtypes to complement C1q.
AuthorsVerardi S, Page RC, Ammons WF, Bordin S
JournalJ Periodontal Res
PubMed ID17214641
The pathogenesis of periodontitis includes an inappropriate activation of the classical complement cascade (C') with accumulation of inflammatory C' products in fluids and tissues. Our hypothesis is that in vivo the C' product, C1q, may act as a regulatory component of the innate immune response of distinct matrix fibroblasts to ... More
MCP-1 production in temporomandibular joint inflammation.
AuthorsOgura N, Satoh K, Akutsu M, Tobe M, Kuyama K, Kuboyama N, Sakamaki H, Kujiraoka H, Kondoh T
JournalJ Dent Res
PubMed ID20647497
Synovitis, which is characterized by the infiltration of inflammatory cells, often accompanies progression of temporomandibular joint disorder (TMD) symptoms. Because IL-1ß is elevated in synovial fluids obtained from TMDs, we hypothesized that IL-1ß-responsive genes in synoviocytes may help identify the putative genes associated with synovitis. Using microarray analysis, we found ... More
Sarcoptes scabiei (Acari: Sarcoptidae) mite extract modulates expression of cytokines and adhesion molecules by human dermal microvascular endothelial cells.
AuthorsElder BL, Arlian LG, Morgan MS
JournalJ Med Entomol
PubMed ID17017228
The inflammatory and immune responses seen with the worldwide disease scabies, caused by the mite Sarcoptes scabiei (De Geer) (Acari: Sarcoptidae), are complex. Clinical symptoms are delayed for weeks in patients when they are infested with scabies for the first time. This study was undertaken to elucidate the role of ... More
Cytokines produced by cultured human umbilical cord blood (HUCB) cells: implications for brain repair.
The potential therapeutic benefits from human umbilical cord blood (HUCB) cells for the treatment of injuries, diseases, and neurodegeneration are becoming increasingly recognized. The transplantation or infusion of cord blood cells in various animal models, such as ischemia/stroke, traumatic brain injury, myocardial infarction, Parkinson's disease, and amyotropic lateral sclerosis, has ... More
Diisocyanate antigen-stimulated monocyte chemoattractant protein-1 synthesis has greater test efficiency than specific antibodies for identification of diisocyanate asthma.
AuthorsBernstein DI, Cartier A, Côté J, Malo JL, Boulet LP, Wanner M, Milot J, L'Archevéque J, Trudeau C, Lummus Z
JournalAm J Respir Crit Care Med
PubMed ID12186818
We previously reported that diisocyanate-human serum albumin (DIISO-HSA) stimulated production of monocyte chemoattractant protein-1 (MCP-1) by peripheral blood mononuclear cells is significantly associated with a clinical diagnosis of diisocyanate asthma (DA). Others have reported that antibodies for DIISO-HSA are specific but insensitive markers of DA. This study was performed to ... More
LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway.
AuthorsAnand AR, Bradley R, Ganju RK
JournalMol Immunol
PubMed ID18954908
Bacterial endotoxin (lipopolysaccharide or LPS) has potent pro-inflammatory properties and acts on many cell types including endothelial cells. Secretion of the CC chemokine, MCP-1 (CCL2) by LPS-activated endothelial cells contributes substantially to the pathogenesis of sepsis. However, the mechanism involved in LPS-induced MCP-1 production in endothelial cells is not well ... More
Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells.
AuthorsRoda JM, Parihar R, Magro C, Nuovo GJ, Tridandapani S, Carson WE
JournalCancer Res
PubMed ID16397268
In the current report, we have examined the ability of natural killer (NK) cells to produce T cell-recruiting chemokines following dual stimulation with interleukin (IL)-2 or IL-12 and human breast cancer cells coated with an antitumor antibody (trastuzumab). NK cells stimulated in this manner secreted an array of T cell-recruiting ... More
Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
AuthorsLong KZ, Santos JI, Estrada Garcia T, Haas M, Firestone M, Bhagwat J, Dupont HL, Hertzmark E, Rosado JL, Nanthakumar NN
JournalJ Nutr
PubMed ID16988133
The impact of vitamin A supplementation on childhood diarrhea may be determined by the regulatory effect supplementation has on the mucosal immune response in the gut. Previous studies have not addressed the impact of vitamin A supplementation on the production of monocyte chemoattractant protein 1 (MCP-1), an essential chemokine involved ... More