Evidence of T-helper cell 2 cytokine regulation of chronic otitis media with effusion.
AuthorsSmirnova MG, Birchall JP, Pearson JP
JournalActa Otolaryngol
PubMed ID16298784
'Cytokine and cellular patterns of effusions may reflect stages of middle ear inflammation. The local interplay between IL-2 and -4 is likely to play a crucial role in the switching of inflammation in the chronic stage. The T-helper cell 2 (Th2) cytokines IL-4, -5 and -13 and the Th2/Th1 cytokine ... More
Modulation of T cell response to hGAD65 peptide epitopes.
AuthorsMasewicz SA, Papadopoulos GK, Swanson E, Moriarity L, Moustakas AK, Nepom GT
JournalTissue Antigens
PubMed ID12028536
'Human CD4 T cell responses to an epitope of hGAD65 (GAD = glutamic acid decarboxylase), residues 555-567, are modulated by interaction with an altered peptide ligand containing modifications at TCR contact residues. Using different HLA-DR4 molecules with polymorphisms at sites corresponding to peptide binding pockets p1 and p9, we tested ... More
Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset.
AuthorsCooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA
JournalBlood
PubMed ID11342442
'During the innate immune response to infection, monocyte-derived cytokines (monokines), stimulate natural killer (NK) cells to produce immunoregulatory cytokines that are important to the host''s early defense. Human NK cell subsets can be distinguished by CD56 surface density expression (ie, CD56(bright) and CD56(dim)). In this report, it is shown that ... More
Cellular immune responses in human immunodeficiency virus (HIV)-1-infected children: is immune restoration by highly active anti-retroviral therapy comparable to non-progression?
AuthorsHainaut M, Verscheure V, Ducarme M, Schandené L, Levy J, Mascart F
JournalClin Exp Immunol
PubMed ID21501151
'The objective of this study was to investigate whether the restored immune functions of vertically human immunodeficiency virus (HIV)-infected children who were severely immunodeficient before the initiation of highly active anti-retroviral therapy (HAART) are comparable to those of untreated slow progressors. We therefore assessed T cell proliferation and cytokine [interferon ... More
Effects of IL-13 on mucociliary differentiation of pediatric asthmatic bronchial epithelial cells.
'Goblet cell hyperplasia (GCH) and decreased ciliated cells are characteristic of asthma. We examined the effects of IL-13 (2 and 20 ng/mL) on in vitro mucociliary differentiation in pediatric bronchial epithelial cells (PBECs) of normal PBEC [PBEC(N)] and asthmatic PBEC [PBEC(A)] children. Markers of differentiation, real-time PCR for MUC5AC, MUC5AC ... More
Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children.
AuthorsContreras JP, Ly NP, Gold DR, He H, Wand M, Weiss ST, Perkins DL, Platts-Mills TA, Finn PW
JournalJ Allergy Clin Immunol
PubMed ID14657861
The early childhood allergen-induced immune responses associated with atopic disease and IgE production in early life are not well understood.
Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-gamma.
AuthorsGold DR, Willwerth BM, Tantisira KG, Finn PW, Schaub B, Perkins DL, Tzianabos A, Ly NP, Schroeter C, Gibbons F, Campos H, Oken E, Gillman MW, Palmer LJ, Ryan LM, Weiss ST
JournalJ Allergy Clin Immunol
PubMed ID16630954
N-3 and n-6 polyunsaturated fatty acids (PUFAs) have been hypothesized to have opposing influences on neonatal immune responses that might influence the risk of allergy or asthma. However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development. ... More
Absence of mucosal inflammation in uncomplicated diverticular disease.
AuthorsElli L, Roncoroni L, Bardella MT, Terrani C, Bonura A, Ciulla M, Marconi S, Piodi L
JournalDig Dis Sci
PubMed ID21221786
Uncomplicated diverticular disease is a common condition in patients older than 50 years. Symptoms are aspecific and overlapping with those of irritable bowel syndrome. Nowadays, patients are often treated with antinflammatory drugs (5-aminosalicilic acid). ... More
Simultaneous aberrations in Mphi and T cell function adversely affect trauma patients' clinical outcome: a possible faulty IL-13 feedback loop.
AuthorsLaudanski K, De A, Pellegrini J, Miller-Graziano C
JournalClin Immunol
PubMed ID16303333
Possible defective trauma patients' Mphi-T-cell feedback interactions between T cell IL-13 production and IL-1beta and IL-18 Mphi secretion were assessed. Mphi produced IL-1 and IL-18 augment T cell IL-13, which in turn limits excessive macrophage activation. Immunodepressed patients' T cells (depressed proliferation to alphaCD3 + alphaCD4) had decreased IL-13 production ... More
The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion.
AuthorsGibbons FK, Israel E, Deykin A, Schaub B, He HZ, Perkins DL, Finn PW
JournalJ Clin Immunol
PubMed ID16160912
Therapy for asthma often includes the combined use of glucocorticoids and leukotriene receptor antagonists. The short-term, combined effects of these drugs on cytokine secretion and lymphocyte proliferation are ill-defined. The aim of this study was to analyze allergen and mitogen-induced cytokine secretion and lymphocyte proliferation in asthmatics and to determine ... More
Dysregulation of IL-13 production by cord blood CD4+ T cells is associated with the subsequent development of atopic disease in infants.
AuthorsOhshima Y, Yasutomi M, Omata N, Yamada A, Fujisawa K, Kasuga K, Hiraoka M, Mayumi M
JournalPediatr Res
PubMed ID11809914
Early intervention strategies in allergic diseases will be dependent on identification of newborns at high risk for later development of atopic disease. In this cohort study of 106 neonates, we investigated whether cytokine production property and responsiveness to IL-12 of neonatal CD4(+) T cells were associated with the subsequent development ... More
Correlation between eosinophils and protection against reinfection with Schistosoma mansoni and the effect of human immunodeficiency virus type 1 coinfection in humans.
Longitudinal investigations of an adult male population of Kenyan car washers who have heavy and quantifiable occupational exposure to Schistosoma mansoni cercariae revealed that some individuals develop resistance to reinfection while others remain highly susceptible. We sought to characterize immune correlates associated with host protection in this population. Previous studies ... More
A role for IL-10-mediated HLA-DR7-restricted T cell-dependent events in development of the modified Th2 response to cat allergen.
AuthorsReefer AJ, Carneiro RM, Custis NJ, Platts-Mills TA, Sung SS, Hammer J, Woodfolk JA
JournalJ Immunol
PubMed ID14978075
Although high dose exposure to inhaled cat allergen (Fel d 1) can cause a form of tolerance (modified Th2 response), the T cell mechanism for this phenomenon has not been studied. T cell responses to Fel d 1 were characterized in both allergic (IgE(pos)) and modified Th2 (IgE(neg)IgG(pos)) responders as ... More
Effect of monophosphoryl lipid A (MPL) on T-helper cells when administered as an adjuvant with pneumocococcal-CRM197 conjugate vaccine in healthy toddlers.
AuthorsVernacchio L, Bernstein H, Pelton S, Allen C, MacDonald K, Dunn J, Duncan DD, Tsao G, LaPosta V, Eldridge J, Laussucq S, Ambrosino DM, Molrine DC
JournalVaccine
PubMed ID12399193
As new vaccines are developed, novel adjuvants may play an important role in eliciting an effective immune response. We evaluated the safety and adjuvant properties of monophosphoryl lipid A (MPL in 129 healthy toddlers immunized with two doses of nine-valent pneumococcal-CRM(197) protein conjugate vaccine (PCV9) combined with 10, 25, or ... More
The modulation of cytokine and IgE production by tumor necrosis factor-beta in atopic dermatitis.
AuthorsJirapongsananuruk O, Donahue HL, Trumble AE, Leung DY
JournalJ Invest Dermatol
PubMed ID10620139
Atopic dermatitis (AD) is associated with increased IL-4, IL-5, and IL-13 but decreased IFN-gamma production. This cytokine profile may account for the atopic features of this illness, including IgE upregulation. Recent studies have demonstrated that tumor necrosis factor (TNF)-beta is produced by Th1-like cells, but the cytokine modulation by TNF-beta ... More