ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjögrens syndrome-like MRL/lpr mice.
AuthorsGao J, Morgan G, Tieu D, Schwalb TA, Luo JY, Wheeler LA, Stern ME
JournalExp Eye Res
PubMed ID15037117
We previously reported that immune-based inflammation occurs on the ocular surface of humans as well as canines with keratoconjunctivitis sicca (KCS). Intercellular adhesion molecule-1 (ICAM-1) was found to be upregulated on lymphocytes and/or vascular endothelial cells resulting in lymphocytic diapedesis to the lacrimal and conjunctival tissues. The purpose of the ... More
The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice.
AuthorsZhang WJ, Wei H, Frei B
JournalExp Biol Med (Maywood)
PubMed ID20463304
Vascular inflammation and monocyte recruitment are initiating events in atherosclerosis that have been suggested to be caused, in part, by iron-mediated oxidative stress and shifts in the intracellular redox environment of vascular cells. Therefore, the objective of this study was to investigate whether the intracellular iron chelator, desferrioxamine (DFO), reduces ... More