Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice.
AuthorsYamamoto H, Nagase T, Shindo T, Teramoto S, Aoki-Nagase T, Yamaguchi Y, Hanaoka Y, Kurihara H, Ouchi Y,
JournalJ Appl Physiol (1985)
PubMed ID17332272
'Adrenomedullin (ADM), a newly identified vasodilating peptide, is reported to be expressed in lungs and have a bronchodilating effect. We hypothesized whether ADM could be involved in the pathogenesis of bronchial asthma. We examined the role of ADM in airway responsiveness using heterozygous ADM-deficient mice (AM+/-) and their littermate control ... More
A multimeric immunogen for the induction of immune memory to beta-amyloid.
AuthorsMantile F, Basile C, Cicatiello V, De Falco D, Caivano A, De Berardinis P, Prisco A,
JournalImmunol Cell Biol
PubMed ID21102534
The development of active immunotherapy for Alzheimer's disease (AD) requires the identification of immunogens that can ensure a high titer antibody response toward beta-amyloid, whereas minimizing the risks of a cell-mediated adverse reaction. We describe here two novel anti-beta-amyloid vaccines that consist of 'virus like particles' formed by a domain ... More
Th1-type immune response to a Coccidioides immitis antigen delivered by an attenuated strain of the non-invasive enteropathogen Vibrio cholerae.
AuthorsSilva AJ, Benitez JA,
JournalFEMS Immunol Med Microbiol
PubMed ID15708313
The antigen-2 or proline rich antigen (Ag2/PRA) from Coccidioides immitis, known to protect mice against experimental Coccidioidomycosis, was expressed in the genetically attenuated cholera vaccine candidate Vibrio cholerae 638 and its thymine auxotrophic derivative 638T. Intranasal immunization of mice with strains producing Ag2/PRA induced serum vibriocidal antibody and Ag2/PRA-specific total ... More