Leptin alters antibody isotype in the pig in vivo, but does not regulate cytokine expression or stimulate STAT3 signaling in peripheral blood monocytes in vitro.
AuthorsWeber TE, Spurlock ME
JournalJ Anim Sci
PubMed ID15216988
'Although leptin modulates immunological pathways in some species, the role of leptin as a regulator of immunocyte function in the pig has not been studied. Therefore, the primary objective of this study was to determine whether leptin influences specific immunocyte response variables in the pig in vivo or in vitro. ... More
Physiological response to superantigen-adsorbing hemoperfusion in toxin-concentration-controlled septic swine.
AuthorsMiwa K, Fukuyama M, Matsuno N, Shimada K, Ikeda K, Ikeda T
JournalBlood Purif
PubMed ID16534194
Superantigens are suspected of being potent initiators of gram-positive sepsis, and new therapies for superantigen elimination are required. The effects of hemoadsorption with a superantigen-adsorbing device (SAAD) were evaluated in septic swine. ... More
Superantigen-induced multiple organ dysfunction in a toxin-concentration-controlled and sequential parameter-monitored swine sepsis model.
AuthorsMiwa K, Fukuyama M, Matsuno N, Masuda S, Oyama Y, Ikeda K, Ikeda T
JournalInt J Infect Dis
PubMed ID16263316
In order to examine the biological activity of low-dose and continuously infused superantigen, and to establish a superantigen-induced multiple organ dysfunction animal model, several pathophysiological parameters were sequentially monitored in a toxin-concentration-controlled pig model. ... More