AuthorsGao J, Duan Z, Zhang L, Huang X, Long L, Tu J, Liang H, Zhang Y, Shen T, Lu F
Journal
PubMed ID26942056
Dysfunction of natural killer (NK) cells has been implicated in the failure of antitumor immune responses in hepatocellular carcinoma (HCC) patients. However, the changes of NK profile in peripheral blood after surgery and tumor tissues of HCC patients, as well as the underlying reason and the significance are vague. Here, ... More
Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV.
AuthorsTorrentes-Carvalho A, Hottz ED, Marinho CF, da Silva JB, Pinto LM, Fialho LG, Bozza FA, Cunha RV, Damasco PV, Kubelka CF, de Azeredo EL
JournalClin Immunol
PubMed ID26826597
'The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients presented mild clinical manifestations of dengue infection. Herein, we show that DENV/HIV coinfected patients had higher CD8 T ... More
A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.
AuthorsWunderlich M, Stockman C, Devarajan M, Ravishankar N, Sexton C, Kumar AR, Mizukawa B, Mulloy JC
JournalJCI Insight
PubMed ID27699249
Transgenic expression of key myelosupportive human cytokines in immune-deficient mice corrects for the lack of cross-species activities of stem cell factor (SCF), IL-3, and GM-CSF. When engrafted with human umbilical cord blood (UCB), these triple-transgenic mice produce BM and spleen grafts with much higher myeloid composition, relative to nontransgenic controls. ... More
No effect of anti-TNF-a agents on the surgical stress response in patients with inflammatory bowel disease undergoing bowel resections: a prospective multi-center pilot study.
AuthorsEl-Hussuna A, Qvist N, Zangenberg MS, Langkilde A, Siersma V, Hjort S, Gögenur I
JournalBMC Surg
PubMed ID30390672
TNF-a plays a role in angiogenesis and collagen synthesis, both essential in the wound healing process. There are concerns that pre-operative anti-TNF-a treatment may influence the surgical stress response and increase the risk of surgical complications. The aim of this study was to describe the surgical stress response in patients ... More