Natural aging and Alzheimer’s disease pathology increase susceptibility to focused ultrasound-induced blood–brain barrier opening
AuthorsR. L. Noel, A. J. Batts, R. Ji, A. N. Pouliopoulos, S. Bae, A. R. Kline-Schoder & E. E. Konofagou
JournalScientific Reports
PubMed ID
Focused Ultrasound (FUS) paired with systemically-injected microbubbles (μB) is capable of transiently opening the blood–brain barrier (BBBO) for noninvasive and targeted drug delivery to the brain. FUS-BBBO is also capable of modulating the neuroimmune system, further qualifying its therapeutic potential for neurodegenerative diseases like Alzheimer’s disease (AD). Natural aging and ... More