Deconvolution of the Response to Bacillus Calmette-Guérin Reveals NF-?B-Induced Cytokines As Autocrine Mediators of Innate Immunity.
AuthorsBisiaux A, Boussier J, Duffy D, Quintana-Murci L, Fontes M, Albert ML
JournalFront Immunol
PubMed ID28751891
Bacillus Calmette-Guérin (BCG) is used as a vaccine and diagnostic test for tuberculosis, as well as immunotherapy in the treatment of bladder cancer. While clinically useful, the response to mycobacterial stimulation is complex and the induced protein signature remains poorly defined. We characterized the cell types directly engaged by BCG, ... More
Alpha fetoprotein (AFP) is produced by over 50% of hepatocellular carcinomas (HCC). Uptake of tumor-derived AFP (tAFP) can impair activity of human dendritic cells (DC). The expression pattern of the lipid antigen presenting genes from the CD1 family is reduced in AFP-treated monocyte-derived DC. Surface CD1 family proteins, particularly CD1d, ... More
Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients.
AuthorsLiu M, Guo Q, Wu C, Sterlin D, Goswami S, Zhang Y, Li T, Bao C, Shen N, Fu Q, Zhang X
JournalCell Mol Immunol
PubMed ID29563616
A hallmark of systemic lupus erythematosus (SLE) is the breaking of B-cell tolerance with the generation of high-affinity autoantibodies; however, the antibody-independent features of the B-cell compartment in SLE are less understood. In this study, we performed an extensive examination of B-cell subsets and their proinflammatory properties in a Chinese ... More