Image based Machine Learning for identification of macrophage subsets.
AuthorsRostam HM, Reynolds PM, Alexander MR, Gadegaard N, Ghaemmaghami AM
JournalSci Rep
PubMed ID28615717
'Macrophages play a crucial rule in orchestrating immune responses against pathogens and foreign materials. Macrophages have remarkable plasticity in response to environmental cues and are able to acquire a spectrum of activation status, best exemplified by pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes at the two ends of the spectrum. Characterisation ... More
Identification of a TLR2 Inhibiting Wheat Hydrolysate.
AuthorsKiewiet MBG, Dekkers R, van Gool MP, Ulfman LH, Groeneveld A, Faas MM, de Vos P
JournalMol Nutr Food Res
PubMed ID30354027
'Wheat hydrolysates are used in medical nutrition to provide undernourished patients a readily digestible protein source, for instance to recover from chemotherapy-induced intestinal mucosal inflammation. Since many hydrolysates of different sources can modulate the immune system, likely via Toll-like receptors (TLRs), it is hypothesized that also wheat hydrolysates might interact ... More