Mucosal-associated invariant T (MAIT) cells are depleted and prone to apoptosis in cardiometabolic disorders.
AuthorsTouch S, Assmann KE, Aron-Wisnewsky J, Marquet F, Rouault C, Fradet M, Mosbah H, Consortium M, Isnard R, Helft G, Lehuen A, Poitou C, Clément K, André S
JournalFASEB J
PubMed ID29957059
The disruption of systemic immune homeostasis is a key mediator in the progression of cardiometabolic diseases (CMDs). We aimed to extend knowledge regarding the clinical relevance of CMD-associated variation of circulating mucosal-associated invariant T (MAIT) cell abundance and to explore underlying cellular mechanisms. We analyzed cross-sectional data from 439 participants ... More