Immune activation in prolonged cART-suppressed HIV patients is comparable to that of healthy controls.
Authorsvan den Dries L, Claassen MAA, Groothuismink ZMA, van Gorp E, Boonstra A
JournalVirology
PubMed ID28644978
'Sustained immune activation during chronic HIV infection is considered to augment co-morbidity and mortality. Effective combination antiretroviral therapy (cART) has shown to dampen immune activation especially during the first year cART, but the effects of long-term cART in patients without major comorbidities remains under-investigated. We performed a comprehensive analysis including ... More
The host response in critically ill sepsis patients on statin therapy: a prospective observational study.
AuthorsWiewel MA, Scicluna BP, van Vught LA, Hoogendijk AJ, Zwinderman AH, Lutter R, Horn J, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T
JournalAnn Intensive Care
PubMed ID29349709
'Statins can exert pleiotropic anti-inflammatory, vascular protective and anticoagulant effects, which in theory could improve the dysregulated host response during sepsis. We aimed to determine the association between prior statin use and host response characteristics in critically ill patients with sepsis.' ... More
Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study.
AuthorsWiewel MA, Huson MA, van Vught LA, Hoogendijk AJ, Klein Klouwenberg PM, Horn J, Lutter R, Cremer OL, Schultz MJ, Bonten MJ, van der Poll T
JournalCrit Care
PubMed ID27719675
'Sepsis is a prominent reason for intensive care unit (ICU) admission in patients with HIV. We aimed to investigate the impact of HIV infection on presentation, outcome and host response in sepsis.' ... More
Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients.
AuthorsClaushuis TA, van Vught LA, Scicluna BP, Wiewel MA, Klein Klouwenberg PM, Hoogendijk AJ, Ong DS, Cremer OL, Horn J, Franitza M, Toliat MR, Nürnberg P, Zwinderman AH, Bonten MJ, Schultz MJ, van der Poll T
JournalBlood
PubMed ID26956172
Preclinical studies have suggested that platelets influence the host response during sepsis. We sought to assess the association of admission thrombocytopenia with the presentation, outcome, and host response in patients with sepsis. Nine hundred thirty-one consecutive sepsis patients were stratified according to platelet counts (very low <50 × 10(9)/L, intermediate-low ... More
Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients.
Authorsvan Vught LA, Scicluna BP, Hoogendijk AJ, Wiewel MA, Klein Klouwenberg PM, Cremer OL, Horn J, Nürnberg P, Bonten MM, Schultz MJ, van der Poll T
JournalCrit Care
PubMed ID27495247
Diabetes is associated with chronic inflammation and activation of the vascular endothelium and the coagulation system, which in a more acute manner are also observed in sepsis. Insulin and metformin exert immune modulatory effects. In this study, we aimed to determine the association of diabetes and preadmission insulin and metformin ... More