Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines.
AuthorsHarting TP, Stubbendorff M, Hammer SC, Schadzek P, Ngezahayo A, Murua Escobar H, Nolte I
JournalPLoS One
PubMed ID28591165
'Targeting mitochondrial energy metabolism is a novel approach in cancer research and can be traced back to the description of the Warburg effect. Dichloroacetate, a controversially discussed subject of many studies in cancer research, is a pyruvate dehydrogenase kinase inhibitor. Dichloroacetate causes metabolic changes in cancerous glycolysis towards oxidative phosphorylation ... More
The effect of dichloroacetate in canine prostate adenocarcinomas and transitional cell carcinomas in vitro.
AuthorsHarting T, Stubbendorff M, Willenbrock S, Wagner S, Schadzek P, Ngezahayo A, Murua Escobar HM, Nolte I
JournalInt J Oncol
PubMed ID27748833
'The Warburg effect describes the ability of cancer cells to produce energy via aerobic glycolysis instead of oxidative phosphorylation of pyruvate. This deviation in mitochondrial metabolism inhibits apoptosis, allowing increased proliferation under conditions of reduced oxygen levels. Dichloroacetate (DCA) was successfully used in several human cancer cell lines to reactivate ... More