Loss of T-bet confers survival advantage to influenza-bacterial superinfection.
AuthorsEr JZ, Koean RAG, Ding JL
JournalEMBO J
PubMed ID30322895
'The transcription factor, T-bet, regulates type 1 inflammatory responses against a range of infections. Here, we demonstrate a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection. Interestingly, we found that T-bet deficiency did not adversely affect the efficacy of viral clearance or recovery compared to wild-type hosts. ... More