Bioactive nanoparticle-based formulations increase survival area of perforator flaps in a rat model.
AuthorsLese I, Graf DA, Tsai C, Taddeo A, Matter MT, Constantinescu MA, Herrmann IK, Olariu R
JournalPLoS One
PubMed ID30475867
'Distal flap necrosis is a frequent complication of perforator flaps. Advances in nanotechnology offer exciting new therapeutic approaches. Anti-inflammatory and neo-angiogenic properties of certain metal oxides within the nanoparticles, including bioglass and ceria, may promote flap survival. Here, we explore the ability of various nanoparticle formulations to increase flap survival ... More