Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset.
AuthorsDunham J, van Driel N, Eggen BJ, Paul C, 't Hart BA, Laman JD, Kap YS
JournalClin Transl Immunology
PubMed ID28243437
Despite the well-known association of Epstein-Barr virus (EBV), a lymphocryptovirus (LCV), with multiple sclerosis, a clear pathogenic role for disease progression has not been established. The translationally relevant experimental autoimmune encephalomyelitis (EAE) model in marmoset monkeys revealed that LCV-infected B cells have a central pathogenic role in the activation of ... More
Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.
AuthorsFisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M, Silvestri G, Chahroudi A, Klatt NR, Sodora DL
JournalPLoS Pathog
PubMed ID29466439
Liver disease is a leading contributor to morbidity and mortality during HIV infection, despite the use of combination antiretroviral therapy (cART). The precise mechanisms of liver disease during HIV infection are poorly understood partially due to the difficulty in obtaining human liver samples as well as the presence of confounding ... More