NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent of myocardial damage after myocardial infarction (MI). The purpose of this study was to investigate the effects of the NLRP3-inflammasome inhibitor IZD334 on cardiac damage in a pig model of myocardial infarction. Prior to in vivo testing, in vitro, porcine ... More
Development of podophyllotoxin-loaded nanostructured lipid carriers for the treatment of condyloma acuminatum.
AuthorsGao Y, Han K, Wang Q, Hu Z, Liu Q, Liu L, Zeng K
JournalMol Med Rep
PubMed ID29512736
'Condyloma acuminatum (CA) is a common sexually transmitted disease caused by human papillomavirus (HPV). Podophyllotoxin (POD), a cytotoxic compound, is able to effectively treat HPV; however, the severe irritation side effects of POD restrict its use as a treatment for CA. The aim of the present study was to construct ... More