Attenuation of Follicular Helper T Cell-Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjögren's Syndrome.
AuthorsVerstappen GM, Meiners PM, Corneth OBJ, Visser A, Arends S, Abdulahad WH, Hendriks RW, Vissink A, Kroese FGM, Bootsma H,
JournalArthritis Rheumatol
PubMed ID28564491
'To assess the effect of abatacept (CTLA-4Ig), which limits T cell activation, on homeostasis of CD4+ T cell subsets and T cell-dependent B cell hyperactivity in patients with primary Sjögren''s syndrome (SS). Fifteen patients with primary SS treated with abatacept were included. Circulating CD4+ T cell and B cell subsets ... More
No difference in human mast cells derived from peanut allergic versus non-allergic subjects.
AuthorsLarsen LF, Juel-Berg N, Hansen A, Hansen KS, Mills ENC, van Ree R, Rådinger M, Poulsen LK, Jensen BM
JournalImmun Inflamm Dis
PubMed ID29992767
Mast cells are the primary effector cells of allergy. This study aimed at characterizing human peripheral blood-derived mast cells (PBdMC) from peanut allergic and non-allergic subjects by investigating whether the molecular and stimulus-response profile of PBdMC discriminate between peanut allergic and healthy individuals. ... More
HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses.
AuthorsAmelio P, Portevin D, Hella J, Reither K, Kamwela L, Lweno O, Tumbo A, Geoffrey L, Ohmiti K, Ding S, Pantaleo G, Daubenberger C, Perreau M
JournalJ Virol
PubMed ID30541853
Human immunodeficiency virus (HIV) infection is the major risk factor predisposing for