Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.
AuthorsNiemi JP, Filous AR, DeFrancesco A, Lindborg JA, Malhotra NA, Wilson GN, Zhou B, Crish SD, Zigmond RE
JournalExp Neurol
PubMed ID28645526
Neuropathy is a major diabetic complication. While the mechanism of this neuropathy is not well understood, it is believed to result in part from deficient nerve regeneration. Work from our laboratory established that gp130 family of cytokines are induced in animals after axonal injury and are involved in the induction ... More