Serum Markers in Rheumatoid Arthritis: A Longitudinal Study of Patients Undergoing Infliximab Treatment.
AuthorsSelaas O, Nordal HH, Halse AK, Brun JG, Jonsson R, Brokstad KA
Journal
PubMed ID26788062
Objective. The aim of this study was to investigate the clinical effect and serum markers in a cohort of rheumatoid arthritis patients with moderate to high disease activity, participating in an open clinical phase IV study conducted in Norway between 2001 and 2003 receiving infliximab treatment. Method. A total of ... More
Adaptive processes of Staphylococcus aureus isolates during the progression from acute to chronic bone and joint infections in patients.
AuthorsTrouillet-Assant S, Lelièvre L, Martins-Simões P, Gonzaga L, Tasse J, Valour F, Rasigade JP, Vandenesch F, Muniz Guedes RL, Ribeiro de Vasconcelos AT, Caillon J, Lustig S, Ferry T, Jacqueline C, Loss de Morais G, Laurent F
JournalCell Microbiol
PubMed ID26918656
'Staphylococcus aureus bone and joint infection (BJI) is associated with significant rates of chronicity and relapse. In this study, we investigated how S. aureus is able to adapt to the human environment by comparing isolates from single patients with persisting or relapsing BJIs that were recovered during the initial and ... More
Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment.
AuthorsKordasti S, Costantini B, Seidl T, Perez Abellan P, Martinez Llordella M, McLornan D, Diggins KE, Kulasekararaj A, Benfatto C, Feng X, Smith A, Mian SA, Melchiotti R, de Rinaldis E, Ellis R, Petrov N, Povoleri GA, Chung SS, Thomas NS, Farzaneh F, Irish JM, Heck S, Young NS, Marsh JC, Mufti GJ
JournalBlood
PubMed ID27281795
Idiopathic aplastic anemia (AA) is an immune-mediated and serious form of bone marrow failure. Akin to other autoimmune diseases, we have previously shown that in AA regulatory T cells (Tregs) are reduced in number and function. The aim of this study was to further characterize Treg subpopulations in AA and ... More
Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory T
AuthorsLou Y, Hu M, Wang Q, Yuan M, Wang N, Le F, Li L, Huang S, Wang L, Xu X, Jin F
JournalInt J Biol Sci
PubMed ID28529452
A pro-inflammatory cytokine profile at the feto-maternal interface may predispose immune maladaptation notably in early miscarriages. We investigated the involvement of estradiol (E
Lymphocyte subsets are influenced by positivity levels in healthy subjects before and after mild acute stress.
AuthorsCaprara GV, Nisini R, Castellani V, Vittorio P, Alessandri G, Vincenzo Z, Claudia F, Valentina G, Andrea PD, Biondo MI, Milanetti F, Salerno G, Vincenzo V, Mario P, Aniballi E, Simonetta S, Angela S, D'Amelio R
JournalImmunol Lett
PubMed ID28539270
In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acute stress test, in 41 healthy ... More
Distinctive Responses in an In Vitro Human Dendritic Cell-Based System upon Stimulation with Different Influenza Vaccine Formulations.
AuthorsTapia-Calle G, Stoel M, de Vries-Idema J, Huckriede A
JournalVaccines (Basel)
PubMed ID28792466
Vaccine development relies on testing vaccine candidates in animal models. However, results from animals cannot always be translated to humans. Alternative ways to screen vaccine candidates before clinical trials are therefore desirable. Dendritic cells (DCs) are the main orchestrators of the immune system and the link between innate and adaptive ... More