Transcript-activated collagen matrix as sustained mRNA delivery system for bone regeneration.
AuthorsBadieyan ZS, Berezhanskyy T, Utzinger M, Aneja MK, Emrich D, Erben R, Schüler C, Altpeter P, Ferizi M, Hasenpusch G, Rudolph C, Plank C
JournalJ Control Release
PubMed ID27586186
Transcript therapies using chemically modified messenger RNAs (cmRNAs) are emerging as safe and promising alternatives for gene and recombinant protein therapies. However, their applications have been limited due to transient translation and relatively low stability of cmRNAs compared to DNA. Here we show that vacuum-dried cmRNA-loaded collagen sponges, termed transcript ... More