Lymphocyte-independent pathways underlie the pathogenesis of murine cytomegalovirus-associated secondary haemophagocytic lymphohistiocytosis.
AuthorsBrisse E, Imbrechts M, Mitera T, Vandenhaute J, Berghmans N, Boon L, Wouters C, Snoeck R, Andrei G, Matthys P
JournalClin Exp Immunol
PubMed ID29178470
Haemophagocytic lymphohistiocytosis (HLH) constitutes a spectrum of immunological disorders characterized by uncontrolled immune activation and key symptoms such as fever, splenomegaly, pancytopenia, haemophagocytosis, hyperferritinaemia and hepatitis. In genetic or primary HLH, hyperactivated CD8 ... More