Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes.
AuthorsLucifora J, Bonnin M, Aillot L, Fusil F, Maadadi S, Dimier L, Michelet M, Floriot O, Ollivier A, Rivoire M, Ait-Goughoulte M, Daffis S, Fletcher SP, Salvetti A, Cosset FL, Zoulim F, Durantel D
JournalSci Rep
PubMed ID29599452
Current therapies for chronic hepatitis B virus (HBV) infections are effective at decreasing the viral load in serum, but do not lead to viral eradication. Recent studies highlighted the therapeutic or "adjuvant" potential of immune-modulators. Our aim was to explore the direct anti-HBV effect of Toll-Like-Receptors (TLR) agonists in hepatocytes. ... More
Effect of atorvastatin on humoral immune response to 23-valent pneumococcal polysaccharide vaccination in healthy volunteers: The StatVax randomized clinical trial.
AuthorsWildes TJ, Grippin A, Fasanya H, Dyson KA, Brantly M
JournalVaccine
PubMed ID30686636
The immunomodulatory effects of statins on vaccine response remain uncertain. Therefore, the objective of this study was to determine if atorvastatin enhances pneumococcal-specific antibody titer following 23-valent pneumococcal polysaccharide vaccination. ... More
NK Cells Activated through Antibody-Dependent Cell Cytotoxicity and Armed with Degranulation/IFN-? Production Suppress Antibody-dependent Enhancement of Dengue Viral Infection.
AuthorsSun P, Williams M, Nagabhushana N, Jani V, Defang G, Morrison BJ
JournalSci Rep
PubMed ID30710094
Antibody (Ab)-dependent enhancement (ADE) is a hypothesized mechanism of increased disease severity during secondary dengue virus (DENV) infection. This study investigates Ab-dependent cell cytotoxicity (ADCC) in counteracting ADE. In our system, DENV and DENV-immune sera were added to peripheral blood mononuclear cells (PBMCs), and ADE and NK cell activation were ... More