Bacterial translocation and barrier dysfunction enhance colonic tumorigenesis.
AuthorsZhang Y,Zhang J,Xia Y,Sun J
JournalNeoplasia (New York, N.Y.)
PubMed ID36334333
In the development of colon cancer, the intestinal dysbiosis and disruption of barrier function are common manifestations. In the current study, we hypothesized that host factors, e.g., vitamin D receptor deficiency or adenomatous polyposis coli (APC) mutation, contribute to the enhanced dysbiosis and disrupted barrier in the pathogenesis of colorectal ... More
Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.
AuthorsWun K, Theriault BR, Pierre JF, Chen EB, Leone VA, Harris KG, Xiong L, Jiang Q, Spedale M, Eskandari OM, Chang EB, Ho KJ
JournalPLoS One
PubMed ID30521585
The microbiome has a functional role in a number of inflammatory processes and disease states. While neointimal hyperplasia development has been linked to inflammation, a direct role of the microbiota in neointimal hyperplasia has not yet been established. Germ-free (GF) mice are an invaluable model for studying causative links between ... More
Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice.
Rift Valley fever (RVF) in humans is usually mild, but, in a subset of cases, can progress to severe hepatic and neurological disease. Rodent models of RVF generally develop acute severe clinical disease. Here, we inoculated humanized NSG-SGM3 mice with Rift Valley fever virus (RVFV) to investigate whether the presence ... More