Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.
AuthorsMoser M, Bauer M, Schmid S, Ruppert R, Schmidt S, Sixt M, Wang HV, Sperandio M, Fässler R,
JournalNat Med
PubMed ID19234461
Integrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell-specific FERM domain protein Kindlin-3 is required for the activation of the beta1 and beta3 integrins on platelets. Impaired activation of beta1, beta2 and beta3 integrins on platelets and leukocytes is the hallmark ... More
A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis.