Visualizing regional myocardial blood flow in the mouse.
AuthorsKrueger MA, Huke SS, Glenny RW,
JournalCirc Res
PubMed ID23513055
The spatial distribution of blood flow in the hearts of genetically modified mice is a phenotype of interest because derangements in blood flow may precede detectable changes in organ function. However, quantifying the regional distribution of blood flow within organs of mice is challenging because of the small organ volume ... More
Multiplexed spectral signature detection for microfluidic color-coded bioparticle flow.
Here, we report a high-speed photospectral detection technique capable of discriminating subtle variations of spectral signature among fluorescently labeled cells and microspheres flowing in a microfluidic channel. The key component used in our study is a strain-tunable nanoimprinted grating microdevice coupled with a photomultiplier tube (PMT). The microdevice permits acquisition ... More