Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages.
AuthorsBenten WP,Lieberherr M,Stamm O,Wrehlke C,Guo Z,Wunderlich F
JournalMolecular biology of the cell
PubMed ID10512854
Testosterone acts on cells through intracellular transcription-regulating androgen receptors (ARs). Here, we show that mouse IC-21 macrophages lack the classical AR yet exhibit specific nongenomic responses to testosterone. These manifest themselves as testosterone-induced rapid increase in intracellular free [Ca(2+)], which is due to release of Ca(2+) from intracellular Ca(2+) stores. ... More