Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes.
AuthorsZhang JW, Tang QQ, Vinson C, Lane MD
JournalProc Natl Acad Sci U S A
PubMed ID14688407
'Hormonal induction of growth-arrested 3T3-L1 preadipocytes rapidly activates expression of CCAAT/enhancer-binding protein (C/EBP) beta. Acquisition of DNA-binding activity by C/EBPbeta, however, is delayed until the cells synchronously enter the S phase of mitotic clonal expansion (MCE). After MCE, C/EBPbeta activates expression of C/EBPalpha and peroxisome proliferator-activated receptor gamma, which then ... More
In vivo imaging platform for tracking immunotherapeutic cells.
AuthorsAhrens ET, Flores R, Xu H, Morel PA
JournalNat Biotechnol
PubMed ID16041364
Cellular therapeutics show great promise for the treatment of disease, but few noninvasive techniques exist for monitoring the cells after administration. Here we present a magnetic resonance imaging (MRI) technology that uses perfluoropolyether (PFPE) agents to track cells in vivo. Fluorine MRI selectively images only the labeled cells, and a ... More
ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells.
AuthorsRyten M, Dunn PM, Neary JT, Burnstock G
JournalJ Cell Biol
PubMed ID12135987
ATP is well known for its role as an intracellular energy source. However, there is increasing awareness of its role as an extracellular messenger molecule (Burnstock, 1997). Although evidence for the presence of receptors for extracellular ATP on skeletal myoblasts was first published in 1983 (Kolb and Wakelam), their physiological ... More
5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells.
AuthorsGöoz M, Göoz P, Luttrell LM, Raymond JR
JournalJ Biol Chem
PubMed ID16737974
In this study, we present multiple lines of evidence to support a critical role for heparin-bound EGF (epidermal growth factor)-like growth factor (HB-EGF) and tumor necrosis factor-alpha-converting enzyme (TACE) (ADAM17) in the transactivation of EGF receptor (EGFR), ERK phosphorylation, and cellular proliferation induced by the 5-HT(2A) receptor in renal mesangial ... More
Small proline-rich repeat 3 is a novel coordinator of PDGFRβ and integrin β1 crosstalk to augment proliferation and matrix synthesis by cardiac fibroblasts.
Authors
JournalFASEB J
PubMed ID32297675
Cellular tropism of human enterovirus D species serotypes EV-94, EV-70, and EV-68 in vitro: implications for pathogenesis.
Authors
JournalJ Med Virol
PubMed ID20872722
Vitronectin receptors, alpha v integrins, are recognized by several non-RGD-containing echoviruses in a continuous laboratory cell line and also in primary human Langerhans' islets and endothelial cells.
Authors
JournalJ Gen Virol
PubMed ID19776235
Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.
Authors
JournalEndocrinology
PubMed ID29029116
SNAIL is induced by tamoxifen and leads to growth inhibition in invasive lobular breast carcinoma.
Authors
JournalBreast Cancer Res Treat
PubMed ID30798422
Simple and effective serum-free medium for sustained expansion of bovine satellite cells for cell cultured meat.
Authors
JournalCommun Biol
PubMed ID35654948
Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma.
Authors
JournalCancer Lett
PubMed ID31229512
Engineering carotenoid production in mammalian cells for nutritionally enhanced cell-cultured foods.
Authors
JournalMetab Eng
PubMed ID32890703
Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1.