Control of integrin alphaIIb beta3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates.
AuthorsPodolnikova NP, Yermolenko IS, Fuhrmann A, Lishko VK, Magonov S, Bowen B, Enderlein J, Podolnikov AV, Ros R, Ugarova TP,
JournalBiochemistry
PubMed ID19929007
The physical properties of substrates are known to control cell adhesion via integrin-mediated signaling. Fibrin and fibrinogen, the principal components of hemostatic and pathological thrombi, may represent biologically relevant substrates whose variable physical properties control adhesion of leukocytes and platelets. In our previous work, we have shown that binding of ... More
mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets.
AuthorsWeyrich AS, Denis MM, Schwertz H, Tolley ND, Foulks J, Spencer E, Kraiss LW, Albertine KH, McIntyre TM, Zimmerman GA,
JournalBlood
PubMed ID17110454
'New activities of human platelets continue to emerge. One unexpected response is new synthesis of proteins from previously transcribed RNAs in response to activating signals. We previously reported that activated human platelets synthesize B-cell lymphoma-3 (Bcl-3) under translational control by mammalian target of rapamycin (mTOR). Characterization of the ontogeny and ... More
Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets.
A unique aspect of integrin receptor function is the transmission of bidirectional signals. In platelets alphaIIbbeta3 integrins require
Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.
AuthorsBezman NA, Lian L, Abrams CS, Brass LF, Kahn ML, Jordan MS, Koretzky GA,
JournalJ Exp Med
PubMed ID18663126
Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP76), an adaptor that plays a critical role in platelet activation in vitro, contains three N-terminal tyrosine residues that are essential for its function. We demonstrate that mice containing complementary tyrosine to phenylalanine mutations in Y145 (Y145F) and Y112 and Y128 ... More
Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair.
Authors
JournalNat Commun
PubMed ID33883558
PAI1 mediates fibroblast-mast cell interactions in skin fibrosis.
Authors
JournalJ Clin Invest
PubMed ID29584619
Nanoscale binding site localization by molecular distance estimation on native cell surfaces using topological image averaging.
Authors
JournalElife
PubMed ID35200140
Mechanochemical Crosstalk Produces Cell-Intrinsic Patterning of the Cortex to Orient the Mitotic Spindle.
Authors
JournalCurr Biol
PubMed ID32735816
Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation.
Authors
JournalNat Cell Biol
PubMed ID27548916
Cell barrier function of resident peritoneal macrophages in post-operative adhesions.
Authors
JournalNat Commun
PubMed ID33854051
Anti-Platelet Effect Induced by Iron Oxide Nanoparticles: Correlation with Conformational Change in Fibrinogen.
Authors
JournalSmall
PubMed ID33284518
Advanced Microfluidic Device Designed for Cyclic Compression of Single Adherent Cells.
Authors
JournalFront Bioeng Biotechnol
PubMed ID30386779
Stress fibres are embedded in a contractile cortical network.
Authors
JournalNat Mater
PubMed ID33077951
Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium.