Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.
AuthorsHammer F, Compagnone NA, Vigne JL, Bair SR, Mellon SH
JournalEndocrinology
PubMed ID14576192
'Steroid hormones are synthesized in adrenals, gonads, placenta, and the central and peripheral nervous systems (neurosteroids). Neurosteroidogenesis, like conventional steroidogenesis, begins with the conversion of cholesterol to pregnenolone, catalyzed by mitochondrial P450 side-chain cleavage enzyme (P450scc). Transcription of the P450scc gene in the adrenals and gonads requires steroidogenic factor-1, which ... More