Surface-functionalized nanoparticles for targeted gene delivery across nasal respiratory epithelium.
AuthorsSundaram S, Roy SK, Ambati BK, Kompella UB,
JournalFASEB J
PubMed ID19608628
'The objective of this study was to determine whether surface-modified nanoparticles enhance permeability across nasal mucosa, while retaining the effectiveness of the payload. The uptake and permeability of polystyrene nanoparticles (PS-NPs; FluoSpheres) was evaluated across the various regions of the bovine nasal epithelia following conjugation with deslorelin and transferrin. Uptake ... More
A two-photon fluorescence-correlation study of lectins interacting with carbohydrated 20 nm beads.
AuthorsPohl WH, Hellmuth H, Hilbert M, Seibel J, Walla PJ
JournalChembiochem
PubMed ID16408309
We present results of a two-photon fluorescence-correlation study carried out with glycosylated and untreated 20 nm fluorescing spheres that interacted with the carbohydrate-binding proteins soybean agglutinin (SBA) and concanavalin A (Con A). The assay principle allows protein-carbohydrate binding interactions to be determined without protein labeling. This assay might serve as ... More