Fractal nature of regional ventilation distribution.
AuthorsAltemeier WA, McKinney S, Glenny RW
JournalJ Appl Physiol
PubMed ID10797111
'High-resolution measurements of pulmonary perfusion reveal substantial spatial heterogeneity that is fractally distributed. This observation led to the hypothesis that the vascular tree is the principal determinant of regional blood flow. Recent studies using aerosol deposition show similar ventilation heterogeneity that is closely correlated with perfusion. We hypothesize that ventilation ... More
Macelignan inhibits melanosome transfer mediated by protease-activated receptor-2 in keratinocytes.
AuthorsChoi EJ, Kang YG, Kim J, Hwang JK,
JournalBiol Pharm Bull
PubMed ID21532167
'Skin pigmentation is the result of melanosome transfer from melanocytes to keratinocytes. Protease-activated receptor-2 (PAR-2) is a key mediator of melanosome transfer, which occurs as the melanocyte extends its dendrite toward surrounding keratinocytes that take up melanosomes by phagocytosis. We investigated the effects of macelignan isolated from Myristica fragrans HOUTT. ... More
Estimated functional diameter of alveolar septal microvessels in zone 1.
AuthorsConhaim RL, Rodenkirch LA
JournalAm J Physiol
PubMed ID8853334
'To estimate the functional diameter of alveolar septal microvessels in zone 1, we perfused isolated rat lungs with fluorescent latex particles of specific diameters (0.24, 0.49, 1.05, or 4.0 microns) at pulmonary artery pressures (Ppulmart) that were either 5 or 10 cmH2O less than the air inflation pressure (Pinflat, 25 ... More
A murine scavenger receptor MARCO recognizes polystyrene nanoparticles.
AuthorsKanno S, Furuyama A, Hirano S,
JournalToxicol Sci
PubMed ID17361018
'Recent toxicological studies indicate that nanoparticles or ultrafine particles (< 100 nm) are more toxic than fine particles (< 2 microm) because of their greater surface area. It is well known that alveolar macrophages play an important role in the first defense against various environmental particles and microorganisms. This is ... More
Stresses at the cell-to-substrate interface during locomotion of fibroblasts.
AuthorsDembo M, Wang YL
JournalBiophys J
PubMed ID10096925
Recent technological improvements in the elastic substrate method make it possible to produce spatially resolved measurements of the tractions exerted by single motile cells. In this study we have applied these developments to produce maps of the tractions exerted by 3T3 fibroblasts during steady locomotion. The resulting images have a ... More
Rho is involved in superoxide formation during phagocytosis of opsonized zymosans.
AuthorsKim JS, Diebold BA, Kim JI, Kim J, Lee JY, Park JB
JournalJ Biol Chem
PubMed ID14970220
Phagocytosis is accompanied by the production of superoxide by the NADPH oxidase complex, for which GTP-bound Rac is essential. We wanted to determine whether Rho is also involved in the production of superoxide during phagocytosis. Inhibition of Rho by Tat-C3 exoenzyme (Tat-C3) blocked superoxide formation and curtailed the phagocytosis of ... More