Fractal nature of regional ventilation distribution.
AuthorsAltemeier WA, McKinney S, Glenny RW
JournalJ Appl Physiol
PubMed ID10797111
'High-resolution measurements of pulmonary perfusion reveal substantial spatial heterogeneity that is fractally distributed. This observation led to the hypothesis that the vascular tree is the principal determinant of regional blood flow. Recent studies using aerosol deposition show similar ventilation heterogeneity that is closely correlated with perfusion. We hypothesize that ventilation ... More
Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion.
AuthorsGlenny RW, Bernard S, Brinkley M
JournalJ Appl Physiol
PubMed ID8335595
'Estimations of dog lung, pig heart, and pig kidney regional perfusion by use of fluorescent-labeled microspheres were compared with measurements obtained with standard radiolabeled microspheres. Pairs of radio- and fluorescent-labeled microspheres (15 microns diam, 6 colors) were injected into a central vein of a supine anesthetized dog and the left ... More
Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparation.
AuthorsFletcher AJ, Forhead AJ, Fowden AL, Ford WR, Nathanielsz PW, Giussani DA,
JournalJ Physiol
PubMed ID15513943
Structural and functional maturation of a number of fetal organs and physiological systems occurs in the immediate period prior to term, in association with the prepartum increase in fetal plasma cortisol concentration. At present, little is known about how myocardial sensitivity to adrenergic and muscarinic cholinergic stimulation changes as the ... More
Fluorescent microspheres to measure organ perfusion: validation of a simplified sample processing technique.
A disadvantage of nonradioactive microsphere techniques is that the processing of samples is time-consuming and complex. We developed and validated a simplified processing method for the fluorescent microsphere (FM) technique. In seven anesthetized dogs with coronary artery stenosis up to six different FM and five different radioactivity labeled microspheres (RM) ... More