Phosphatidylinositide 3-kinase priming couples c-FLIP to T cell activation.
AuthorsFang LW, Tai TS, Yu WN, Liao F, Lai MZ,
JournalJ Biol Chem
PubMed ID14578361
Cellular FLICE (FADD-like interleukin-1-beta-converting enzyme)-inhibitory protein (c-FLIP) inhibits death receptor-induced apoptosis by binding to FADD (Fas-associated death domain protein) and pro-caspase-8. c-FLIP has also been shown to transmit activation signals and to enhance interleukin (IL)-2 production. However, c-FLIP-mediated T cell activation is difficult to detect in most cells. We found ... More