Activity of human IgG and IgA subclasses in immune defense against Neisseria meningitidis serogroup B.
AuthorsVidarsson G,van Der Pol WL,van Den Elsen JM,Vilé H,Jansen M,Duijs J,Morton HC,Boel E,Daha MR,Corthésy B,van De Winkel JG
JournalJournal of immunology (Baltimore, Md. : 1950)
PubMed ID11342648
Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme, NADH-dependent fumarate reductase.
AuthorsBesteiro S, Biran M, Biteau N, Coustou V, Baltz T, Canioni P, Bringaud F
JournalJ Biol Chem
PubMed ID12138089
In all trypanosomatids, including Trypanosoma brucei, glycolysis takes place in peroxisome-like organelles called glycosomes. These are closed compartments wherein the energy and redox (NAD(+)/NADH) balances need to be maintained. We have characterized a T. brucei gene called FRDg encoding a protein 35% identical to Saccharomyces cerevisiae fumarate reductases. Microsequencing of ... More
ClC-3 is a fundamental molecular component of volume-sensitive outwardly rectifying Cl- channels and volume regulation in HeLa cells and Xenopus laevis oocytes.
AuthorsHermoso M, Satterwhite CM, Andrade YN, Hidalgo J, Wilson SM, Horowitz B, Hume JR
JournalJ Biol Chem
PubMed ID12183454
Volume-sensitive osmolyte and anion channels (VSOACs) are activated upon cell swelling in most vertebrate cells. Native VSOACs are believed to be a major pathway for regulatory volume decrease (RVD) through efflux of chloride and organic osmolytes. ClC-3 has been proposed to encode native VSOACs in Xenopus laevis oocytes and in ... More