Abnova

CXCR3 Monoclonal Antibody (1C5)

Name: CXCR3 Monoclonal Antibody (1C5)
Brand: Abnova
SKU: H00002833-M01A

查看其他58个CXCR3抗体

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

Additional Information:

Immunogen image

Immunogen Image CXCR3 Monoclonal Antibody (1C5)

产品信息

H00002833-M01A

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

产品规格

种属反应

Human

宿主/亚型

Mouse / IgM, kappa

分类

Monoclonal

类型

Antibody

克隆号

1C5

抗原

CXCR3 (NP_001495.1, 1 a.a. approximately 53 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

保存液

ascites

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: MVLEVSDHQV LNDAEVAALL ENFSSSYDYG ENESDSCCTS PPCPQDFSLN FDR

靶标信息

CD183, also known as CXCR3, is a seven-transmembrane G protein-coupled chemokine receptor that binds CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC), which are part of the CXC chemokine subfamily. CD183 plays a crucial role in leukocyte traffic, influencing integrin activation, cytoskeletal changes, and chemotactic migration. It is expressed on NK cells, subsets of T lymphocytes, regulatory T cells (Tregs), and is preferentially found on Th1-polarized cells. CD183 is prominently expressed in effector/memory T cells and T cells in inflamed tissues, contributing to CD4 T cell responses to grafts, as evidenced by compromised allograft rejection in CXCR3 knockout mice. Chemokine binding induces rapid, short-lived cellular responses due to receptor internalization, with responsiveness restored after receptor recycling. Inhibition by Bordetella pertussis toxin suggests coupling with Gi subclass G proteins. The production of IP-10, Mig, and I-TAC in inflammatory lesions indicates CD183 role in recruiting inflammatory cells, making it a target for developing antagonists to treat inflammatory diseases. Multiple transcript variants encoding different isoforms of CD183 have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: an; C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 3; CC motif chemokine; CCmotif chemokine; CD183; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C motif) receptor 3 isoform CXCR3_1; chemokine (C-X-C motif) receptor 3 isoform CXCR3_2; chemokine receptor 3; CKR-L2; CXC; CXC motif chemokine; CXC-R3; CXCR3-B; G protein-coupled receptor; G protein-coupled receptor; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; IP10; IP10 receptor; Mig receptor; unnamed protein product

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基因别名: CD182; CD183; CKR-L2; CMKAR3; CXCR3; GPR9; IP10-R; Mig-R; MigR

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UniProt ID: (Human) P49682

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Entrez Gene ID: (Human) 2833

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功能

G-protein coupled receptor activity chemokine receptor activity protein binding C-C chemokine receptor activity C-X-C chemokine receptor activity chemokine binding C-C chemokine binding C-X-C chemokine binding signaling receptor activity

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