Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry.
AuthorsRadoshitzky SR, Warfield KL, Chi X, Dong L, Kota K, Bradfute SB, Gearhart JD, Retterer C, Kranzusch PJ, Misasi JN, Hogenbirk MA, Wahl-Jensen V, Volchkov VE, Cunningham JM, Jahrling PB, Aman MJ, Bavari S, Farzan M, Kuhn JH,
JournalJ Virol
PubMed ID21697477
With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and
Inhibition of Ebola virus entry by a C-peptide targeted to endosomes.
AuthorsMiller EH, Harrison JS, Radoshitzky SR, Higgins CD, Chi X, Dong L, Kuhn JH, Bavari S, Lai JR, Chandran K,
JournalJ Biol Chem
PubMed ID21454542
Ebola virus (EboV) and Marburg virus (MarV) (filoviruses) are the causative agents of severe hemorrhagic fever. Infection begins with uptake of particles into cellular endosomes, where the viral envelope glycoprotein (GP) catalyzes fusion between the viral and host cell membranes. This fusion event is thought to involve conformational rearrangements of ... More
Evaluation of high-throughput screening for in vitro micronucleus test using fluorescence-based cell imaging.
AuthorsShibai-Ogata A, Kakinuma C, Hioki T, Kasahara T,
JournalMutagenesis
PubMed ID21745803
The in vitro micronucleus (MN) test is an important component of genotoxicity screening and is used as an alternative to the in vitro chromosome aberration (CA) test. As the MN assay is more practical and simpler to use than the CA test, it is being applied as a high-throughput screening ... More
Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.
Bone marrow stromal antigen 2 (BST-2/tetherin) is a cellular membrane protein that inhibits the release of HIV-1. We show for the first time, using infectious viruses, that BST-2 also inhibits egress of arenaviruses but has no effect on filovirus replication and spread. Specifically, infectious Lassa virus (LASV) release significantly decreased ... More
IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.
AuthorsMudhasani R, Tran JP, Retterer C, Radoshitzky SR, Kota KP, Altamura LA, Smith JM, Packard BZ, Kuhn JH, Costantino J, Garrison AR, Schmaljohn CS, Huang IC, Farzan M, Bavari S,
Journal
PubMed ID23720721
We show that interferon-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity against several members of the Bunyaviridae family, including Rift Valley fever virus (RVFV), La Crosse virus, Andes virus, and Hantaan virus, all of which can cause severe disease in humans and animals. ... More
Antibody RING-Mediated Destruction of Endogenous Proteins.
Authors
JournalMol Cell
PubMed ID32454028
Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes.
Authors
JournalSTAR Protoc
PubMed ID33997813
MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells.
Authors
JournalSci Rep
PubMed ID34262099
Image-Based Quantitation of Host Cell-Toxoplasma gondii Interplay Using HRMAn: A Host Response to Microbe Analysis Pipeline.
Authors
JournalMethods Mol Biol
PubMed ID31758464
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes.
Authors
JournalElife
PubMed ID29993362
Helicobacter suis binding to carbohydrates on human and porcine gastric mucins and glycolipids occurs via two modes.
Authors
JournalVirulence
PubMed ID29638186
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.
Authors
JournalCommun Biol
PubMed ID34127790
A phenotypic compound screening assay for lysosomal storage diseases.
Authors
JournalJ Biomol Screen
PubMed ID23983233
3D model of harlequin ichthyosis reveals inflammatory therapeutic targets.
Authors
JournalJ Clin Invest
PubMed ID32544098
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia.