Akt-dependent Phosphorylation of p27Kip1 Promotes Binding to 14-3-3 and Cytoplasmic Localization.
Authors Fujita Naoya; Sato Saori; Katayama Kazuhiro; Tsuruo Takashi;
JournalJ Biol Chem
PubMed ID12042314
'In many human cancers, the cyclin-dependent kinase inhibitor p27(Kip1) is expressed at low or undetectable levels. The decreased p27(Kip1) expression allows cyclin-dependent kinase activity to cause cells to enter into S phase and correlates with poor patient survival. Inhibition of serine/threonine kinase Akt signaling by some pharmacological agents or by ... More