In vitro trafficking and efficacy of core-shell nanostructures for treating intracellular Salmonella infections.
AuthorsRanjan A, Pothayee N, Seleem MN, Sriranganathan N, Kasimanickam R, Makris M, Riffle JS,
JournalAntimicrob Agents Chemother
PubMed ID19596872
Nanostructures encapsulating gentamicin and having either amphiphilic (N1) or hydrophilic (N2) surfaces were designed. Flow cytometry and confocal microscopy studies demonstrated a higher rate of uptake for amphiphilic surfaces. A majority of N1 were localized in the cytoplasm, whereas N2 colocalized with the endosomes/lysosomes. Colocalization was not observed between nanostructures ... More
8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers.
AuthorsPolotskaia A, Hoffman S, Krett NL, Shanmugam M, Rosen ST, Bargonetti J,
JournalMol Cancer Ther
PubMed ID22973058
8-Amino-adenosine (8-NH(2)-Ado) is a ribose sugar nucleoside analogue that reduces cellular ATP levels and inhibits mRNA synthesis. Estrogen receptor-negative (ER-) metastatic breast cancers often contain mutant p53; therefore, we asked if 8-NH(2)-Ado could kill breast cancer cells without activating the p53-pathway. Regardless of the breast cancer subtype tested or the ... More