High-performance liquid chromatographic determination of amiloride and its analogues in rat plasma.
AuthorsMeng QC, Chen YF, Oparil S, Cragoe EJ
JournalJ Chromatogr
PubMed ID2211933
Amiloride and its analogs as tools in the study of ion transport.
AuthorsKleyman TR, Cragoe EJ
JournalJ Membr Biol
PubMed ID2852254
Amiloride inhibits most plasma membrane Na+ transport systems. We have reviewed the pharmacology of inhibition of these transporters by amiloride and its analogs. Thorough studies of the Na+ channel, the Na+/H+ exchanger, and the Na+/Ca2+ exchanger, clearly show that appropriate modification of the structure of amiloride will generate analogs with ... More