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Thermo Scientific Chemicals
U0126, 99+%
Selective inhibitor of mitogen-activated protein kinases MEK-1 and MEK-2 | CAS: 109511-58-2 | C18H16N6S2, C18H16N6S2 | 380.49 g/mol
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化学标识符
CAS109511-58-2
IUPAC Name(2Z,3Z)-bis({amino[(2-aminophenyl)sulfanyl]methylidene})butanedinitrile
Molecular FormulaC18H16N6S2
InChI KeyDVEXZJFMOKTQEZ-JYFOCSDGSA-N
SMILESN\C(SC1=CC=CC=C1N)=C(\C#N)/C(/C#N)=C(\N)SC1=CC=CC=C1N
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规格
规格表
规格表Assay from Supplier's CofA≥99.0% (TLC)
Appearance (Color)White to off-white
Assay from Supplier's CofA≥99.0% (HPLC)
FormPowder or crystals or crystalline powder or granules
Melting Point130.0-133.0°C
U0126, is used as a selective MAP Kinase Kinase (MKK, MEK) inhibitor. U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
RUO – Research Use Only
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-30°C to -10°C