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Thermo Scientific Chemicals
Norfloxacin
A synthetic fluoroquinolone antibiotic | CAS: 70458-96-7 | C16H18FN3O3 | 319.336 g/mol
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化学标识符
CAS70458-96-7
IUPAC Name1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Molecular FormulaC16H18FN3O3
InChI KeyOGJPXUAPXNRGGI-UHFFFAOYSA-N
SMILESCCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1CCNCC1
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规格
规格表
规格表Appearance (Color)Cream to yellowish
FormCrystalline powder
Assay (special)≥ 99.0% (dry basis)
Assay (special)Related substances: ≤ 0.5%
Heavy Metals≤ 15 ppm
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It finds it application as a fluorinated quinolone antibacterial. It is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water
Notes
Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep it refrigerated.
Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water
Notes
Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep it refrigerated.
RUO – Research Use Only
General References:
- Gouvea LR, et al. A typical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action.Eur J Med Chem.,2012,5567-73.
- Gómez-Hurtado I, et al. Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis.Hepatology.,2011,53(3), 935-44.