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Thermo Scientific Chemicals
Indomethacin, 99+%
Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID). | CAS: 53-86-1 | C19H16ClNO4 | 357.79 g/mol
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Beilstein497341
CAS53-86-1
ChEBICHEBI:49662
化学名称或材料Indomethacin
颜色White
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Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release
- Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics
- Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation
Applications
- Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions
- Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin
RUO – Research Use Only
General References:
- Mitra, S.; Florez, I.D.; Tamayo, M.E.; Mbuagbaw, L.; Vanniyasingam, T.; Veroniki, A.A.; Zea, A.M.; Zhang, Y.; Sadeghirad, B.; Thabane, L. Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis. JAMA. 2018, 319(12), 1221-1238.
- El-Mashad, A.E.; El-Mahdy, H.; El Amrousy, D.; Elgendy, M. Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates. Eur J Pediatr. 2017, 176(2), 233-240.