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Fexofenadine hydrochloride
H-1 receptor antagonist | CAS: 153439-40-8 | C32H40ClNO4 | 538.13 g/mol
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化学标识符
CAS153439-40-8
IUPAC Namehydrogen 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid chloride
Molecular FormulaC32H40ClNO4
InChI KeyRRJFVPUCXDGFJB-UHFFFAOYNA-N
SMILES[H+].[Cl-].CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1
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规格
规格表
规格表Mass SpecConforms to structure
Appearance (Color)White to pale cream
Assay from Supplier's CofA≥98.0% (HPLC)
FormPowder
Proton NMRConforms to structure
Fexofenadine hydrochloride is used as an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Fexofenadine hydrochloride is used as an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist.
Solubility
Soluble in Dimethyl sulfoxide (50 mM), and methanol.
Notes
Protect from heat. Store away from oxidizing agents.
Fexofenadine hydrochloride is used as an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist.
Solubility
Soluble in Dimethyl sulfoxide (50 mM), and methanol.
Notes
Protect from heat. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- Harold S. Nelson.; Robert Reynolds.; Jolene Mason. Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria.Annals of Allergy, Asthma & Immunology.2000, 84, (5), 517-522.
- Fran Ridout.; Ziba Shamsi.; Robert Meadows.; Sigurd Johnson.; Ian Hindmarch. A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car.Clinical Therapeutics.2003, 25, (5), 1518-1538.
- Fran Ridout.; Ziba Shamsi.; Robert Meadows.; Sigurd Johnson.; Ian Hindmarch. A single-center, randomized, double-blind, placebo-controlled, crossover investigation of the effects of fexofenadine hydrochloride 180 mg alone and with alcohol, with hydroxyzine hydrochloride 50 mg as a positive internal control, on aspects of cognitive and psychomotor function related to driving a car.Clinical Therapeutics.2003, 25, (5), 1518-1538.