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Thermo Scientific Chemicals
1,4-Dithio-DL-threitol, Electrophoresis Grade, 99%
CAS: 3483-12-3 | C4H10O2S2 | 154.24 g/mol
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化学标识符
CAS3483-12-3
IUPAC Name(2R,3R)-1,4-disulfanylbutane-2,3-diol
Molecular FormulaC4H10O2S2
InChI KeyVHJLVAABSRFDPM-IMJSIDKUSA-N
SMILESO[C@@H](CS)[C@@H](O)CS
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规格表1,4-Dithio-DL-threitol is used as a protective agent for preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide reduction. It is also useful for stabilizing sulfhydryl-containing enzymes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1,4-Dithio-DL-threitol is used as a protective agent for preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide reduction. It is also useful for stabilizing sulfhydryl-containing enzymes.
Solubility
Soluble in water, ethanol, chloroform, diethyl ether, acetone, ether and ethyl acetate.
Notes
Air and heat sensitive. Hygroscopic. Incompatible with strong oxidizing agents, reducing agents and alkalies.
1,4-Dithio-DL-threitol is used as a protective agent for preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide reduction. It is also useful for stabilizing sulfhydryl-containing enzymes.
Solubility
Soluble in water, ethanol, chloroform, diethyl ether, acetone, ether and ethyl acetate.
Notes
Air and heat sensitive. Hygroscopic. Incompatible with strong oxidizing agents, reducing agents and alkalies.
RUO – Research Use Only
General References:
- Tobolkina, E.; Salazar, F. C.; Qiao, L.; Girault, H. H. Protein/peptide purification by three-well OFFGEL electrophoresis with immobilized ultra narrow pH gradient gels. Anal. Methods 2014, 6 (12), 3995-4002.
- Fujita, K.; Muraki, T.; Sakurai, T.; Oishi, A.; Taguchi, Y. Synthesis of Novel Dendritic α-Glycol Ligands Derived from DL-Dithiothreitol and Their Application to Ring-opening Polymerization of ε-Caprolactone. Chem. Lett. 2004, 34 (8), 1180-1181.