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Thermo Scientific Chemicals
3'-Azido-3'-deoxythymidine, 98%
Anti-viral agent | CAS: 30516-87-1 | C10H13N5O4 | 267.25 g/mol
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化学标识符
CAS30516-87-1
IUPAC Name1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Molecular FormulaC10H13N5O4
InChI KeyHBOMLICNUCNMMY-CFQLRCIDNA-N
SMILESCC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
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规格
规格表
规格表Appearance (Color)White to yellow
FormPowder
Assay from Supplier's CofA≥97.5%
Infrared spectrumConforms
3'-Azido-3'-deoxythymidine is a Anti-viral agent, and also used as a reverse transcriptase inhibitor active against HIV-1 virus that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. 3?-Azido-3?-deoxythymidine enters CNS by diffusion and causes irreversible telomere shortening.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
3′-Azido-3′-deoxythymidine is a Anti-viral agent, and also used as a reverse transcriptase inhibitor active against HIV-1 virus that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. 3′-Azido-3′-deoxythymidine enters CNS by diffusion and causes irreversible telomere shortening.
Solubility
Soluble in water.
Notes
Light Sensitive & Hygroscopic. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
3′-Azido-3′-deoxythymidine is a Anti-viral agent, and also used as a reverse transcriptase inhibitor active against HIV-1 virus that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. 3′-Azido-3′-deoxythymidine enters CNS by diffusion and causes irreversible telomere shortening.
Solubility
Soluble in water.
Notes
Light Sensitive & Hygroscopic. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only
General References:
- Hashem Heiati.; Rashad Tawashi.; Nigel C Phillips. Solid lipid nanoparticles as drug carriers: II. Plasma stability and biodistribution of solid lipid nanoparticles containing the lipophilic prodrug 3'-azido-3'-deoxythymidine palmitate in mice. International Journal of Pharmaceutics. 1998, 174, (1-2), 71-80.
- Chris Meier.; Eric De Clercq.; Jan Balzarini. Nucleotide Delivery from cycloSaligenyl-3'-azido-3'-deoxythymidine Monophosphates (cycloSal-AZTMP). European Journal of Organic Chemistry. 1998, 1998, (5), 837-846.