Compound profiling using a panel of steroid hormone receptor cell-based assays.
AuthorsWilkinson JM, Hayes S, Thompson D, Whitney P, Bi K,
JournalJ Biomol Screen
PubMed ID18753690
'A major focus in the current discovery of drugs targeting nuclear receptors (NRs) is identifying drugs with reduced side effects by improving selectivity, not only from other receptors but also by selective modulation of the NR of interest. Cellular assays not only provide valuable information on functional activity, potency, and ... More