Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata.
AuthorsNunn MA, Sharma A, Paesen GC, Adamson S, Lissina O, Willis AC, Nuttall PA,
JournalJ Immunol
PubMed ID15699138
Blood-feeding ticks must control C activation or be damaged by the host inflammatory response. We report the characterization and expression of a novel, relatively small, broad-acting C inhibitory protein (termed OmCI) from the soft tick Ornithodoros moubata. The native 17-kDa nonglycosylated protein inhibits both human and guinea pig classical and ... More