Genetic and epigenetic incompatibilities underlie hybrid dysgenesis in Peromyscus.
AuthorsVrana PB, Fossella JA, Matteson P, del Rio T, O'Neill MJ, Tilghman SM
JournalNature Genetics
PubMed ID10802670
'Crosses between the two North American rodent species Peromyscus polionotus (PO) and Peromyscus maniculatus (BW) yield parent-of-origin effects on both embryonic and placental growth. The two species are approximately the same size, but a female BW crossed with a male PO produces offspring that are smaller than either parent. In ... More
Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner.
Authors Fraser Paul D; Romer Susanne; Shipton Cathie A; Mills Philippa B; Kiano Joy W; Misawa Norihiko; Drake Rachel G; Schuch Wolfgang; Bramley Peter M;
JournalProc Natl Acad Sci U S A
PubMed ID11805345
'Phytoene synthase from the bacterium Erwinia uredovora (crtB) has been overexpressed in tomato (Lycopersicon esculentum Mill. cv. Ailsa Craig). Fruit-specific expression was achieved by using the tomato polygalacturonase promoter, and the CRTB protein was targeted to the chromoplast by the tomato phytoene synthase-1 transit sequence. Total fruit carotenoids of primary ... More
Reduction of false positives in prokaryotic mRNA differential display [In Process Citation]
AuthorsNagel A, Fleming JT, Sayler GS
JournalBiotechniques
PubMed ID10343902
Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis.
AuthorsRuiz-Perez VL, Ide SE, Strom TM, Lorenz B, Wilson D, Woods K, King L, Francomano C, Freisinger P, Spranger S, Marino B, Dallapiccola B, Wright M, Meitinger T, Polymeropoulos MH, Goodship J
JournalNature Genetics
PubMed ID10700184
Ellis-van Creveld syndrome (EvC, MIM 225500) is an autosomal recessive skeletal dysplasia characterized by short limbs, short ribs, postaxial polydactyly and dysplastic nails and teeth. Congenital cardiac defects, most commonly a defect of primary atrial septation producing a common atrium, occur in 60% of affected individuals. The disease was mapped ... More
Immunogene therapy of tumors with vaccine based on Xenopus homologous vascular endothelial growth factor as a model antigen.
Authors Wei Y Q; Huang M J; Yang L; Zhao X; Tian L; Lu Y; Shu J M; Lu C J; Niu T; Kang B; Mao Y Q; Liu F; Wen Y J; Lei S; Luo F; Zhou L Q; Peng F; Jiang Y; Liu J Y; Zhou H; Wang Q R; He Q M; Xiao F; Lou Y Y; Xie X J; Li Q; Wu Y; Ding Z Y; Hu B; Hu M; Zhang W;
JournalProc Natl Acad Sci U S A
PubMed ID11553767
Overcoming immune tolerance of the growth factors associated with tumor growth should be a useful approach to cancer therapy by active immunity. We used vascular endothelial growth factor (VEGF) as a model antigen to explore the feasibility of the immunogene tumor therapy with a vaccine based on a single xenogeneic ... More